-synuclein, that is a key ingredient of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, that is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) anxiety, suggest that dysfunction on the intracellular proteinase systems, such as ubiquitin-proteasome procedure or lysosomal process, which removes unneeded toxic proteins

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